Pharmacokinetics & Drug Delivery | Drug Discovery & Design | Neuropharmacology & Psychopharmacology | Schizophrenia & Other Psychoses | Methods for Diagnostic & Therapeutic Studies
Exploring glutamatergic and cholinergic dose-response in schizophrenia using a novel quantitative systems pharmacology approach
Hugo Geerts*, Athan Spiros, Patrick Roberts
*Corresponding author: Hugo Geerts
In Silico Biosciences, Berwyn, PA, USA
Universtiy of Pennsyvania, Philadelphia, PA, USA
F1000Posters 2012, 3: 675 (poster) [English]
Poster [1.99 MB]
67th Society of Biological Psychiatry Annual Meeting 2012, 3 - 5 May 2012, 994
Many dose-responses of CNS drugs do have an inverse U-shape, due to the complex non-linear interactions between neuronal brain circuits. Knowing the nature of these pharmacodynamics is essential to increase the success of clinical trials.
Both mGluR2 modulators and a7 nAChR are shown to have an inverse U-shape dose-response, irrespective of the off-target effect of the medications.
Integrating this quantitative systems pharmacology in an early stage of drug discovery and development will hopefully improve the clinical trial design.
No relevant competing interests disclosed.
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