Neurobiology of Disease & Regeneration | Neuronal Signaling Mechanisms | Neuropharmacology & Psychopharmacology | Mood Disorders | Methods for Diagnostic & Therapeutic Studies
CoQ 10 may improve mood and energy conditions in bipolar depressed brain
Chun Zuo*, Brent Forester, Caitlin Ravichandran, Fei Du, Bruce Cohen, Perry Renshaw
*Corresponding author: Chun Zuo
Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
F1000Posters 2012, 3: 588 (poster) [English]
Poster [546.74 KB]
67th Society of Biological Psychiatry Annual Meeting 2012, 2 - 4 May 2012, 933
To evaluate if Coenzyme Q 10 (CoQ 10 ) may improve mood and energy conditions in older patients with bipolar depression. Specifically, mood was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS), and energy conditions were assessed with 31P-magnetic resonance spectroscopy (31P-MRS) to measure the forward rate constant (Kfor) of creatine kinase (CK) enzymatic activity before and after an 8-week treatment with CoQ 10 .
CoQ 10 improved mood condition at week 4 in the 8-week treatment, but its impact on the energy condition needs to be determined with a larger sample size.
To evaluate the CoQ 10 treatment efficacy in a larger group of patients with bipolar depression.
Figures 4 and 6 were reproduced with kind permission from Forester BP et al (2012) J Geriatr Psychiatry Neurol. 25(1): 43-50
No relevant competing interests disclosed.
National Institutes of Health (NIH), DA015116
NARSAD, K23 077287-¬‐01
Rogers Family Foundation, R21MH081076
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