Cardiovascular Pharmacology | Social & Behavioral Determinants of Health | Psychological Challenges & Issues for Women | Headache
Aspirin resistance is common in premenopausal women with migraine
Jill T Jesurum*, Cindy J Fuller, Natalia Murinova, Elisa A McGee, Lisa E Hales, Ernesto Tolentino, Sylvia M Lucas
*Corresponding author: Jill T Jesurum
Swedish Heart and Vascular Institute, Swedish Medical Center, Seattle, WA, USA
F1000Posters 2012, 3: 637 (poster) [English]
Poster [401.85 KB]
54th American Headache Society Annual Meeting 2012, 21 - 24 Jun 2012, P105 LB
Women with migraine are at higher risk of stroke than women without migraine. Aspirin is a first-line antiplatelet drug for stroke prevention; however, an earlier study found that 24% of migraineurs, all women, had platelets that were resistant to aspirin 325 mg. The purpose of this study is to assess the prevalence of platelet resistance to aspirin 81 mg in premenopausal women with and without migraine.
Five (23.8%) migraineurs and five (31.3%) controls were found to have aspirin resistance (p = 0.72). Aspirin resistance may be more related to sex than migraine diagnosis.
Further study is needed to assess the efficacy of antiplatelet interventions in women at elevated risk for stroke, such as migraineurs with high monthly frequency.
No relevant competing interests disclosed.
National Headache Foundation, None
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