Hematopoietic Stem Cells | Stem Cells & Regeneration
SIRT1 deficiency compromises mouse embryonic stem cell differentiation, and embryonic and adult hematopoiesis in the mouse
Xuan Ou*, Hee-Don Chae, Rui-Hong Wang, William C Shelley, Scott Cooper, Tammi Taylor, Young-June Kim, Chu-Xia Deng, Mervin C Yoder, Hal E Broxmeyer
*Corresponding author: Xuan Ou
Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
F1000Posters 2012, 3: 982 (poster) [English]
Poster [2.83 MB] | Resulting articles
Presented at
52nd American Society of Hematology Annual Meeting 2010,
3 - 6 Dec 2010, Dec 4, 2010
Here, we evaluated the role of sirtuin 1 (SIRT1) in hematopoietic differentiation derived from mouse embryonic stem cells (ESCs) and hematopoiesis during embryonic development.
SIRT1 plays an important role in ESC hematopoietic differentiation and mouse hematopoiesis.
No relevant competing interests disclosed.
National Institutes of Health (NIH), RO1 HL56416
National Institutes of Health (NIH), RO1 HL 67384
National Institutes of Health (NIH), PO1 HL 53586
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