Neuronal Signaling Mechanisms | Headache
Localization and co-localization of the migraine triggers nNOS, PACAP and CGRP in trigeminal ganglion and trigeminal nucleus caudalis
Roshni Ramachandran, Anders Hay-Schmidt, Jes Olesen, Inger Jansen-Olesen*
*Corresponding author: Inger Jansen-Olesen
Department of Neurology and Danish Headache Center, Glostrup Hospital, Glostrup, Denmark
Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
F1000Posters 2012, 3: 631 (poster) [English]
Poster [2.29 MB]
Presented at
54th American Headache Society Annual Meeting 2012,
21 - 24 Jun 2012, P78
Nitric oxide (NO), pituitary adenylate cyclase-activating polypeptide (PACAP) and calcitonin gene related peptide (CGRP) have been shown to cause migraine attacks in migraineurs. We have studied the localization and co-localization of these signaling substances in the migraine relevant tissues, namely the trigeminal ganglion and trigeminal nucleus caudalis.
Nitric oxide synthase (NOS), PACAP and CGRP were all observed in the trigeminal ganglion and trigeminal nucleus caudalis. There is anatomical evidence for NOS, PACAP and CGRP to modify each others effect within the trigeminal system.
No relevant competing interests disclosed.
Lundbeck Foundation Center for Neurovascular signaling (LUCENS), .
Novo Nordisk Foundation, .
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