Theoretical & Computational Neuroscience | Neurobiology of Disease & Regeneration | Anxiety Disorders
Altered properties in the cortical thickness network of patients with obsessive-compulsive disorder
Seung-Goo Kim, Moo K Chung*, Wi Hoon Jung, Joon Hwan Jang, Jun Soo Kwon
*Corresponding author: Moo K Chung
Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA
Waisman Laboratory for Brain Imaging and Behaviour, University of Wisconsin-Madison, Madison, WI, USA
F1000Posters 2012, 3: 606 (poster) [English]
Poster [4.00 MB]
18th Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2012, 10 - 14 Jun 2012, 208 WTh
Obsessive compulsive disorder (OCD) is an anxiety disorder characterized by intrusive, distressing thoughts and ritualistic, repetitive behaviors. Despite many theory-driven neuroimaging studies, few studies have examined alteration of the whole network in OCD. In this study, we examined the cortico-cortical connectivity using cortical thickness and characterized abnormal network efficiency in OCD.
We found significant group differences in the global efficiency but not in the local efficiency. Additionally, we found significant group differences in neighboring efficiency in the ROIs that are not restricted to the “orbitofronto-striatal” circuits.
Further studies may reveal an alteration of the OCD brain network that has been unattended.
No relevant competing interests disclosed.
KOSEF, MEST, Korea, R31-10089
NRF, MEST, Korea, 2012-0005150
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