Animal Genetics | Endocrinology | Neural Homeostasis | Integrative Physiology | Diabetes & Obesity
Metabolic and hormonal consequences of circadian rhythm disruption in Bmal1 null mice
Joint 15th International Congress of Endocrinology and 14th European Congress of Endocrinology (ICE/ECE) 2012, 5 - 9 May 2012, P1205
There is compelling evidence that disruption of circadian rhythms, particularly disruption of clock gene expression, alters several aspects of metabolism. In this study we report for the first time the effects of global loss of Bmal1 expression on 24 hour plasma adiponectin and leptin as well as expression of adipokine mRNA in adipose tissue. Bmal1 null mice were also subjected to glucose, pyruvate and insulin tolerance tests. Finally we investigated the metabolic impact of a high fat diet in Bmal1 null mice on body and adipose tissue weight, plasma metabolites and hormones.
Bmal1 null mice had increased adiposity and triglycerides compared to the wild type mice but paradoxically had elevated plasma leptin and adiponectin. Bmal1 null mice had mildly impaired insulin secretion but still responded to the high fat diet with increased secretion. Interestingly, they showed evidence of increased gluconeogenesis and glycolysis.
No relevant competing interests disclosed.
National Health and Medical Research Council of Australia, 399131
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