Medical Microbiology | Antimicrobial Agents | Nosocomial & Healthcare-associated Infections | Antimicrobials & Drug Resistance
Genotypic and phenotypic characterization of methicillin-resistant Staphylococcus aureus strains recovered from a Phase IV clinical trial for linezolid versus vancomycin for the treatment of nosocomial pneumonia
Rodrigo E Mendes*, Lalitagauri M Deshpande, Davida S Smith, Bo Shopsin, David J Farrell, Ronald N Jones
*Corresponding author: Rodrigo E Mendes
JMI Laboratories, North Liberty, IA, USA
F1000Posters 2012, 3: 424 (poster) [English]
Poster [662.93 KB] | Recommended by F1000Prime
Presented at
22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2012,
30 Mar - 2 Apr 2012, P1331
A total of 435 methicillin-resistant Staphylococcus aureus (MRSA) baseline isolates were collected from subjects enrolled in a linezolid phase IV nosocomial pneumonia (NP) clinical trial. The aim of this study was to characterize this collection of MRSA strains.
Each region had two predominant clones responsible for NP. The rate of USA300 (21.1%) corroborates previous reports describing increased rates of invasive infections caused by this clone in the USA. The prevalence of hVISA was elevated in Asia, and these strains appear to be associated with CC5.
No relevant competing interests disclosed.
Pfizer Inc., Specialty Care Business Unit, Collegeville, Pennsylvania, USA., NA
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