Toxicology | Musculoskeletal & Dermatologic Pharmacology | Bone Biology, Osteoporosis & Other Diseases of Bone | Bone & Mineral Metabolism
A curious effect in the jaw joint following bisphosphonate treatment
Greetje AP Renders*, GEJ Lagenbach, C Prins, JAF Vermeer, IDC Jansen, TJ de Vries, V Everts
*Corresponding author: Greetje AP Renders
Department of Oral Cell Biology and Functional Anatomy, Academic Center for Dentistry Amsterdam, University of Amsterdam, Amsterdam, Netherlands
F1000Posters 2012, 3: 418 (poster) [English]
Poster [920.40 KB]
European Calcified Tissue Society 39th Annual Congress 2012, 19 - 23 May 2012, PP299
Bisphosphonates (BPs) are commonly used for the treatment of osteoporosis and bone metastases. BPs have a positive treatment effect (e.g., increase in bone tissue density) on the long bones but a negative side effect (e.g., osteonecrosis) on the corpus of the mandible is reported. It is not known whether the jaw joint is also affected by BP treatment. We hypothesize that application of bisphosphonates will affect the jaw joint.
The application of BP resulted in bone-site specific changes in mineralization; an effect that to our knowledge has never been reported before. This regional BP effect might explain the excessive increase in bone volume combined with the lack of increase in mineral density compared to the control group.
Next, the bone analysis results found in the jaw joint will be compared to the knee joint of the same animals. Besides microCT, histological and histomorphometric analysis will be added to the study.
No relevant competing interests disclosed.
Netherlands orginization for scientific research (NWO), 021.001.050
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