Cell Signaling | Control of Gene Expression | Renal, Fluid & Electrolyte Physiology | Acute Renal Failure | Sepsis & Multiple Organ Failure in Critical Care
Age dependent role of microvascular endothelial and polymorphonuclear cells in LPS induced renal failure
FM Wulfert*, M van Meurs, NF Kurniat, RM Jongman, MC Houwertjes, P Heeringa, JG Zijlstra, MMRF Struys, G Molema
*Corresponding author: FM Wulfert
Pathology & Medical Biology, University Medical Center Groningen (UMCG), Groningen, Netherlands
Anaesthesiology, University Medical Center Groningen (UMCG), Groningen, Netherlands
F1000Posters 2012, 3: 366 (poster) [English]
Poster [773.48 KB]
106th American Sociological Association Annual Meeting 2011, 20 - 23 Aug 2011, P000
In this study, we looked at the incidence of acute kidney injury (AKI) following severe sepsis, which is higher in elderly patients. We hypothesized that the microvascular endothelium is “primed” by ageing, and that sepsis represents a “second hit” resulting in more severe microvascular complications in the elderly.
- Ang-2 is increased in older mice, which may cause priming of the endothelial cells.
- Endothelium responded with a more extensive increase in expression of P- and E-selectin in older mice and increased polymorphonuclear neutrophil (PMN) influx.
- Loss of kidney function in aged mice after lipopolysaccharide challenge cannot be prevented by PMN depletion.
No relevant competing interests disclosed.
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