Imaging | Neuromuscular Diseases | Biomarkers
MRI quantification of abnormal muscle water distribution in chronic neuromuscular diseases: a sensitive bio-marker
Jasper M Morrow*, Christopher DJ Sinclair, Arne Fischmann, Mary M Reilly, Michael G Hanna, Tarek A Yosury, John S Thornton
*Corresponding author: Jasper M Morrow
MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology, London, UK
F1000Posters 2012, 3: 355 (poster) [English]
Poster [2.23 MB]
Presented at
UK Neuromuscular Translational Research Conference 2012,
22 - 23 Mar 2012, P93
Quantitative muscle MRI in neuromuscular diseases can measure abnormal muscle water distribution through measurement of T2 relaxation times and the magnetisation transfer (MT) ratio, which may precede fatty infiltration and potentially provide a sensitive biomarker.
We demonstrated abnormal muscle water distribution in calf muscles with Charcot-Marie-Tooth disease Type 1A (CMT1A) and calf and thigh muscles with inclusion body myositis (IBM) using qualitative short-tau inversion-recovery (STIR) and pseudo-quantitative T2 and MT sequences. The differences were greater in IBM patients than in CMT1A patients. The changes were evident in muscles with normal fat fraction, indicating these biomarkers are sensitive to early disease changes.
These methods are currently being extended into a longitudinal study, and may be used in an interventional study in the future.
No relevant competing interests disclosed.
Medical Research Council (MRC), 81007
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