Respiratory Physiology | Respiratory Problems in Critical Care | Airway/Respiratory Physiology
Oxygenation correlates with lung aeration during unsupported spontaneous breathing in a porcine lung collapse model
L Vimlati*, A Larsson, G Hedenstierna, M Licthwarck-Aschoff
*Corresponding author: L Vimlati
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
F1000Posters 2012, 3: 381 (poster) [English]
Poster [621.48 KB]
Presented at
32nd International Symposium on Intensive Care and Emergency Medicine (ISICEM) 2012,
20 - 23 Mar 2012, P121
We investigated whether oxygenation correlates with lung aeration during unsupported spontaneous breathing (SB) and mechanical ventilation (MV) in a porcine lung collapse model.
30 minutes after negative pressure application (NPA), the amount of lung tissue in collapsed regions was similar in both groups (MV: 40% (36 to 44), SB: 35% (26 to 43); P = 0.22). Resuming SB, PaO2/FiO2 improved significantly more with less amount of collapsed lung tissue 2.5 minutes after NPA (r= -0.87, P= 0.033). The less amount of collapsed lung tissue, the higher PaO 2 /FiO 2 was during SB (slope = -1.2 kPa/%; P= 0.0003); no such relationship was seen during MV (slope = -0.3 kPa/%; P= 0.16).
To investigate if this relationship holds true at lower levels of atelectasis.
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No relevant competing interests disclosed.
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