Bioinformatics | Protein Folding | Theory & Simulation | Structural Genomics
Role of physico-chemical properties of amino acids in protein’s structural organization: a network perspective
9th International Conference on Information Processing in Cells and Tissues (IPCAT) 2012, 31 Mar - 2 Apr 2012, P000
Proteins can be presented as networks in which amino acids are the nodes, and their interactions represent undirected edges. Such networks, also called protein contact networks (PCN), can be divided into different sub-networks based on length scales and physico-chemical properties. In this study, we have studied and compared the nature of transition, mixing behavior and local cohesiveness of these sub-networks.
We have shown that the transition behaviour, when plotted as a function of interaction strengths cutoff, differs with different sub-networks. While short-range networks exhibit highly cooperative transition, the long- and all-range networks, which are more similar to each other, show less cooperativity. The presence of larger cluster sized thermophiles than mesophiles in long-range networks at higher interaction strengths suggest that these give extra stability to the tertiary structure of the thermophiles.
No relevant competing interests disclosed.
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