Cell Signaling | Cell Growth & Division | Control of Gene Expression | Gynecological Cancers
LPA-mediated oncogenic signaling in ovarian cancer involves p130Cas
Jeremy D Ward, Danny N Dhanasekaran*
*Corresponding author: Danny N Dhanasekaran
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
The Peggy and Charles Stephenson Oklahoma Cancer Centre, University of Oklahoma Health Sciences Center, Oklahoma, OK, USA
F1000Posters 2012, 3: 254 (poster) [English]
Poster [4.42 MB]
Presented at
American Association for Cancer Research Annual Meeting 2012 ,
31 Mar - 4 Apr 2012, LB-24
Ovarian cancer is currently the most deadly gynecological cancer, but very few advances have been made in its treatment in the last 30 years. Lysophosphatidic acid (LPA) has been identified as a potent signaling molecule that is over-expressed in the micromolar range in 90% of ovarian cancer patients, and has been shown to be directly involved in progression and possibly the genesis of the disease. LPA mediates its oncogenic effects through multiple G protein-coupled receptors; however, the signaling mechanisms by which LPA mediates its oncogenic effects await characterization. Therefore, we sought to identify a critical signaling node that is activated by LPA signaling in ovarian cancer, and to characterize this signaling node’s role in the disease.
LPA-mediated signaling leads to the tyrosine phosphorylation of the scaffold protein p130Cas via a G alpha i2 dependent pathway. Both p130Cas and G alpha i2 are directly involved in mediating LPA-induced migration of ovarian cancer cells.
To identify the LPA receptor(s) that is mediating p130Cas phosphorylation and subsequent LPA-induced migration.
No relevant competing interests disclosed.
National Institutes of Health (NIH), CA116984-06
National Institutes of Health (NIH), CA123233-05
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