Morphogenesis & Cell Biology | Animal Genetics | Control of Gene Expression | Reproductive Physiology
Epigenetic mediated early induction of adipocyte differentiation contributes to programmed obesity in intrauterine growth restricted newborns
59th Society for Gynecologic Investigation Annual Meeting 2012, 20 - 23 Mar 2012, T-117
Intrauterine growth restricted (IUGR) newborns demonstrate programmed adult obesity as a result of early enhanced adipogenesis. As the process of adipogenesis is mediated partly by epigenetic mechanisms, we used primary adipocyte cultures from IUGR and control newborns to study the time course of adipocyte differentiation, including suppression of epigenetic modulators and induction of adipogenic genes.
Primary adipocyte cultures from IUGR newborns indicate early induction of the differentiation process with marked suppression of epigenetic modulators and enhanced expression of adipogenic genes.
No relevant competing interests disclosed.
National Institutes of Health (NIH), 5R01DK081756 NIH/NIDDK
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