Neuronal Signaling Mechanisms | Pharmacokinetics & Drug Delivery | Neuropharmacology & Psychopharmacology | Anesthetic Mechanisms | General Pharmacology
Effect of propofol on acetylcholine release evoked by veratridine in rat hippocampus synaptosomes
FLC Pessoa, LS Monteiro, NS Binda, MV Gomez, RS Gomez*
*Corresponding author: RS Gomez
Surgery Department, Faculty of Medicine, Federal University of Minas Gerais, MInas Gerais, Brazil
F1000Posters 2012, 3: 255 (poster) [English]
Poster [686.36 KB] | Recommended by F1000Prime
Presented at
15th World Congress of Anaesthesiologists 2012,
23 - 28 Mar 2012, P000
Acetylcholine (ACh) is a ubiquitous excitatory neurotransmitter in the brain, involved in the regulation of consciousness, awakening, cognition, memory and sleep. The aim of this study was to evaluate the effect of propofol on ACh release induced by veratridine in rat hippocampus synaptosomes.
Propofol, at clinical and supraclinical concentrations, reduced veratridine- and KCl-evoked ACh release in rat hippocampus synaptosomes in a dose-dependent manner.
To investigate the mechanism by which propofol reduced the evoked release of ACh induced by veratridine and KCl.
No relevant competing interests disclosed.
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