Biocatalysis | Chemical Biology of the Cell | Control of Gene Expression | Liver Biology & Pathobiology
Methionine regeneration by homocysteine remethylation in healthy and tumoral liver tissues
Hélène Pellanda, Bernard Namour, Ma'atem Fofou-Caillierez, Aude Bressenot, Jean-Marc Alberto, Céline Chéry, Ahmet Ayav, Jean-Pierre Bronowicki, Jean-Louis Guéant*, Thierry Forges
*Corresponding author: Jean-Louis Guéant
Faculty of Medicine, Nutrition-génétique et exposition aux risques environnementaux (NGERE), Vandoeuvre-lès-Nancy, France
F1000Posters 2012, 3: 179 (poster) [English]
Advances and Controversies in B-Vitamins and Choline Conference 2012, 4 - 7 Mar 2012, P5 03
The remethylation of homocysteine into methionine is catalyzed by either methionine synthase (MTR) or by betaine-homocysteine methyltransferase (BHMT) in the liver. Choline/betaine deficiency and an impaired BHMT pathway have been associated with hepatocellular carcinogenesis in animal models. The molecular mechanisms that impair the BHMT pathway are unknown. We aimed to investigate BHMT, BHMT2, and MTR expression in both HepG2 cells and human hepatocarcinoma tissues.
A transcription variant of exon 4 produces a loss of function of BHMT in human hepatocarcinoma. This opens new insights for targeting MTR in chemotherapy of hepatocarcinoma. Whether this abnormal transcription of BHMT is part or consequence of liver carcinogenesis warrants further investigation.
No relevant competing interests disclosed.
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