Innate Immunity | Immunity to Infections | Sepsis & Multiple Organ Failure in Critical Care
Modulation of mediators from whole blood or monocytic cells stimulated with lipopolysaccharide reduces endothelial cell activation
Anita Schildberger, Tanja Stoifl, Dieter Falkenhagen, Viktoria Weber*
*Corresponding author: Viktoria Weber
Health Sciences and Biomedicine, Danube University Krems, Krems, Austria
F1000Posters 2012, 3: 196 (poster) [English]
Poster [1.75 MB]
32nd International Symposium on Intensive Care and Emergency Medicine (ISICEM) 2012, 20 - 23 Mar 2012, P012
Modulation of mediators of inflammation with extracorporeal blood purification using selective or specific adsorbents may represent a promising supportive therapy for sepsis.
The aims of this study were;
(1) to modulate concentrations of mediators of inflammation using selective or specific adsorbents in an in vitro cell culture model.
(2) to assess the influence of mediator modulation on endothelial activation.
Modulation of inflammatory mediators using selective or specific adsorbents reduces endothelial cell activation. The effect is more pronounced for selective adsorbents than for specific adsorption of tumor necrosis factor alpha. These findings support the development of extracorporeal therapies for the supportive treatment of sepsis.
The cell culture model will be further developed into a dynamic model that also allows to assess the influence of various cell types, such as neutrophils and platelets.
No relevant competing interests disclosed.
Austrian Research Promotion Agency, FFG Bridge 824914
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