Bioinformatics | Drug Discovery & Design | Toxicology | Molecular Pharmacology
Prediction of cardiac perturbations of non-cardiovascular drugs with My-DTome
Lu Zhang, Yvan Devaux, Daniel R Wagner, Francisco J Azuaje*
*Corresponding author: Francisco J Azuaje
Laboratory of Cardiovascular Research, Public Research Centre for Health (CRP-Santé), Luxembourg, Luxembourg
F1000Posters 2012, 3: 41 (poster) [English]
Poster [1.39 MB] | Resulting articles
Presented at
6th BeNeLux Bioinformatics Conference 2011,
12 - 13 Dec 2011, B6
The molecular mechanisms underlying most cardiac complications of non-cardiovascular drugs are still unknown. Furthermore, there is a need to develop new approaches to predict cardiac effects of non-cardiovascular drugs in both early discovery and post-marketing stages of drug development.
My-DTome provides a systems-based, unbiased strategy to identify cardiovascular complications of non-cardiovascular drugs, and provides insights into molecular mechanisms controlling these side effects.
No relevant competing interests disclosed.
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