Biomacromolecule-Ligand Interactions | Theory & Simulation | Structural Genomics | Molecular Pharmacology
Identification of 6-gingerol target proteins: a structural physico-chemical properties based approach
Rajiv Das Kangabam*, Yumnam Silla, Rajiv Kumar Singh
*Corresponding author: Rajiv Das Kangabam
Bioinformatics centre, Rajiv Gandhi University, Itanagar, Arunachal Pradesh, India
F1000 Posters 2012, 3: 24 (poster) [English]
Poster [1.14 MB]
Presented at
InCoB/ISCB-Asia Joint Conference 2011,
30 Nov - 2 Dec 2011, 30
6-gingerol, a major pharmacologically-active component of ginger, is known to induce anti-oxidant and anti-inflammatory properties, mediating various processes which initiate and promote carcinogenesis and metastasis.
These identified target proteins play an important role in various biological pathways such as hemostasis, epidermal growth factor (EGF) receptor signalling, the coagulation cascade, and pathways in cancer and angiogenesis that are associated with various complex diseases like cardiovascular disorders, stroke, osteoporosis and chronic diseases.
To visualize the conformational changes in the structure of the protein with respect to the binding of 6 gingerol, using molecular dynamics simulation studies.
No relevant conflicts of interest declared.
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