Muscle & Connective Tissue | Cartilage Disorders & Osteoarthritis | Etiology, Pathogenesis & Animal Models of Rheumatic Disease | Diabetes & Obesity | Biomarkers
Adipokines leptin and adiponectin correlate with matrix metalloproteinases and interleukin-6 in synovial fluid from osteoarthritis patients and enhance their production in osteoarthritic cartilage ex vivo
Katriina Vuolteenaho*, Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Eeva Moilanen
*Corresponding author: Katriina Vuolteenaho
The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland
Tampere University Hospital, Tampere, Finland
F1000Posters 2011, 2: 1838 (poster) [English]
75th American College of Rheumatology and Association of Rheumatology Health Professionals (ACR/ARHP) Annual Scientific Meeting 2011, 4 - 8 Nov 2011, 1786
Adipokines leptin and adiponectin regulate energy metabolism and appetite. Interestingly, they have also recently been related to the regulation of inflammatory responses. In arthritis, proteolytic degradation of cartilage is mediated by matrix metalloproteinases (MMPs), and interleukin-6 (IL-6) contributes to inflammation and joint damage.
In the present study, the association of leptin and adiponectin with MMPs and IL-6 in synovial fluid from osteoarthritis (OA) patients was assessed, and the effects of these adipokines on human OA cartilage were investigated.
We found that the adipokines leptin and adiponectin enhanced MMP and IL-6 production in human OA cartilage. The clinical relevance of the finding was supported by the correlations of these mediators in synovial fluid from OA patients. The findings support the idea of leptin and adiponectin as catabolic factors in the pathogenesis of OA, and as possible links between obesity and osteoarthritis.
No relevant competing interests disclosed.
The Academy of Finland, 2010
The Competitive Research Funding of the Pirkanmaa Hospital District, 2010
Päivikki ja Sakari Sohlberg Foundation, 2010
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