Sensory Systems | Neural Homeostasis | Pharmacokinetics & Drug Delivery | Neuropharmacology & Psychopharmacology | Pain: Basic Science | General Pharmacology
Non-steroidal anti-inflammatory drugs analgesia is opioid sensitive in nucleus raphe magnus
N Tsiklauri, I Nozadze, G Gurtskaia, M Tsagareli*
*Corresponding author: M Tsagareli
Department of Neurophysiology, Life Science Research Center, Tbilisi, Georgia
F1000Posters 2011, 2: 1764 (poster) [English]
Poster [162.27 KB]
7th Congress of the European Federation of IASP Chapters (EFIC) 2011, 21 - 24 Sep 2011, S142
European Pain Federation EFIC
The aim of this study was to examine opioid sensitivity of NSAIDs action in the nucleus raphe magnus (NRM) of male rats. 20 minutes after NSAIDs administration, we microinjected mu-opioid antagonist naloxone and tested rats for tail-flick (TF) and hot plate (HP) latencies.
Our results strongly suggest that endogenous opioid release plays a crucial role in NSAIDs antinociception. On the other hand, our evidence confirms once more that NRM is involved in the descending pain control circuit inhibiting spinal nocifensive reflexes.
No relevant competing interests disclosed.
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