Health Systems & Services Research | Methods of Clinical Decision-Making | Statistical Methodologies & Health Informatics | Ethics & Organization in Critical Care & Emergency Medicine | Metabolic Disorders in Critical Care
Comparison of glucose variability measures
Mahuya Bhattacharyya*, SK Todi
*Corresponding author: Mahuya Bhattacharyya
Department of Critical Care & Emergency Medicine, AMRI Hospitals, Kolkata, India
F1000Posters 2011, 2: 351 (poster) [ENGLISH]
Poster [472.77 KB]
31st International Symposium on Intensive Care and Emergency Medicine ISICEM 2011, 20 - 23 Mar 2011, P407
Glycemic excursion or Glucose Variability (GV) is associated with short term ICU mortality. There is heterogeneity among studies in using measures of GV. The objective of this study was to compare different formulas used to assess GV in predicting mortality.
The study was done in a 45 bed medical-surgical unit. All patients who were admitted to ITU and had 4 or more blood glucose (BG) readings were included from January 2009 to November 2009. Sugar control was protocolised with a target CBG of ≤ 150mg/dl. Glucose was measured from central laboratory or point of care checking at an interval
of 6 hours or when required. From the prospectively collected glucose values different measures of glycemic variability have been calculated and compared among themselves. We used SD (Standard Deviation), GLI (Glycemic Lability Index), MGC (Maximum Glucose Change), MAGE (Mean Amplitude of Glucose Excursion) and ADRR (Average Daily Risk Range) as measures of the glucose variability.
A total of 11,335 blood sugar records were analyzed from 2208 patients during this time. Mean age of the study population was 61(SD ± 16.71). 58.96 % were male and 77.8% were medical admission. Mean APACHE IV was 56.9. All the variables of glucose variability could predict mortality with equal power.
All the glucose variability measures have almost the same prediction power. Anyone of the measures can be used as quality indicator of glucose variability in an ICU.
No relevant competing interests disclosed.
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