Submission of the Week
The activation of pattern recognition receptors TLR2, TLR3 and TLR4 – key players in host innate immune defence – induces cellular oxidative stress, which impairs the activity of antioxidant enzymes in intestinal epithelial cells, state the authors of this poster. Intestinal oxidative damage is linked to intestinal inflammation and inflammatory bowel diseases. Toll-like receptors (TLR) provide the first line of defence against pathogen invasion by detecting and recognizing specific evolutionarily-conserved molecular patterns expressed by microbial pathogens and consequently initiating a signaling cascade which leads to the induction of pro-inflammatory and effector cytokines that orchestrate the adaptive immune response.
E Latorre, E Layunta, A Gimeno, L Grasa, ..., B Gros, MA Plaza, JE Mesonero, AI Alcalde Based on: 25th European Intestinal Transport Group Meeting: Spring 2013
Based on: Vision Sciences Society Annual Meeting 2013, Poster ID:1093246
Recent Meetings »
Meetings being covered include:
- » 33rd International Symposium on Intensive Care and Emergency Medicine 2013
- » 17th Annual International Conference on Research in Computational Molecular Biology (RECOMB) 2013
- » 68th Society of Biological Psychiatry Annual Meeting 2013
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Upcoming Meetings »
Meetings we plan to cover include:
- » New York Academy of Sciences - The Bone Marrow Niche, Stem Cells, and Leukemia: Impact of Drugs, Chemicals, and the Environment 2013
- » 23rd Meeting of the European Neurological Society 2013
- » New York Academy of Sciences 2013 - Nanotechnologies in Cancer Diagnosis, Therapy, and Prevention
- » 93rd Annual Meeting of the American Society of Mammalogists 2013
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