Submission of the Week
T cell receptor diversity evaluation to predict patient response to ipilimumab in metastatic melanoma
Ipilimumab blocks the immunologic checkpoint cytotoxic T lymphocyte antigen-4 (CTLA-4) and improves overall survival in patients with metastatic melanoma. Only a subset of patients achieves benefit from ipilimumab: biomarkers that can predict patient outcome are needed. The predictive value of TCR diversity was investigated in this pilot study, by analyzing the baseline (pretreatment) peripheral blood TCR repertoire in stage IV melanoma patients treated with ipilimumab.
M Postow, M Manuel, P Wong, J Yuan, A Courtier, N Pasqual, JD Wolchok Based on: Society for Immunotherapy of Cancer (SITC) Meeting 2014
Based on: Society for Immunotherapy of Cancer (SITC) Meeting 2014, Poster ID:1097401
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