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IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.

Oberoi TK, Dogan T, Hocking JC, Scholz RP, Mooz J, Anderson CL, Karreman C, Meyer zu Heringdorf D, Schmidt G, Ruonala M, Namikawa K, Harms GS, Carpy A, Macek B, Köster RW, Rajalingam K

EMBO J. 2012 Jan 4; 31(1):14-28

Ed Manser, Astar Neuroscience Research Partnership (NRP), Singapore. F1000 Cell Biology

30 Dec 2011 | New Finding, Controversial

This paper is interesting because it describes how Rac1 ubiquitination and degradation may result from the interplay of anti-apoptotic proteins. Rac1 itself has been found to play an anti-apoptotic role perhaps by binding directly to Bcl-2 {1}. Here, the authors show that X-linked inhibitor of apoptosis protein (XIAP) and cellular...

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